Study

A study by Beijing University showed that light sources with full spectral composition caused significantly less damage to the retina and photoreceptors compared to conventional LEDs.

About study

✓ Eyes

Title:

More light components and less light damage on rats’ eyes: evidence for the photobiomodulation and spectral opponency

Author: Jingxin Nie, Ningda Xu, Zhizhong Chen, Lvzhen Huang, Fei Jiao, Yiyong Chen, Zuojian Pan, Chuhan Deng, Haodong Zhang, Boyan Dong, Jiarui Li, Tianchang Tao, Xiangning Kang, Weihua Chen, Qi Wang, Yuzhen Tong, Mingwei Zhao, Guoyi Zhang, Bo Shen Peking University
Date: 7. December 2022
Source: https://doi.org/10.1007/s43630-022-00354-5
PDF: More light components and less light damage on rats’ eyes.PDF

Brief summary

The Chinese study investigated the effects of different light sources on the eyes of rats. Researchers compared the impact of standard white LED light with two low-risk light sources by adding azure (484 nm and 511 nm) and red (664 nm) components to the light spectrum. The rats were exposed to these light sources for seven days, and retinal function, thickness, and expression of autophagy-related proteins were measured. The results showed that incorporating additional light components into the lighting led to less retinal damage, confirming the effectiveness of photobiomodulation (a therapy using low-level light radiation) and spectral opposition effects.

Adding a red spectral component to the light source helps protect the retina from damage by improving mitochondrial function, reducing oxidative stress and autophagy in photoreceptors.

In the experiment, red light of 670 nm wavelength increased mitochondrial membrane potential, accelerated mitochondrial metabolism, and alleviated mitochondrial permeabilisation and receptor autophagy. This implies that the red component in the illumination results in less light damage to the retina.

Multi-spectral low-level LED (LLL) lighting showed less damage to the rat retina than conventional white LEDs

As part of the research, the researchers developed a new ‘low-risk light source’ by adding cyan and red light components to conventional white LEDs. This light source had the same correlated colour temperature (CCT) as a conventional white LED, but resulted in significantly less damage to retinal and photoreceptor function in rats, despite emitting twice the luminance. It has thereby been confirmed that the red component provides a protective effect and the cyan component may have a ‘spectral opposition’ effect that protects the retina by mitigating the attenuation of melatonin associated with light damage.

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