Study

A study from several universities describes the functions of the inner photosensitive ganglion cells of the retina for the proper functioning of circadian rhythms and highlights the importance of the non-visual effects of light and the timing of light exposure for human health and performance.

About study

✓ Overall health

Title:

Melanopsin Vision: Sensation and Perception Through Intrinsically
Photosensitive Retinal Ganglion Cells

Author: Daniel S. Joyce, Kevin W. Houser, Stuart N. Peirson, Jamie M. Zeitzer and Andrew J. Zele The University of British Columbia, University of Nevada, Oregon State University, University of Oxford, Stanford University, Queensland University of Technology
Date: 19. January 2023
Source: https://doi.org/10.1017/9781009029865
PDF: Cambridge University - Melanopsin Vision.PDF

Brief summary

Researchers from leading global universities provide an overview of the importance of intrinsically photosensitive retinal ganglion cells (ipRGC) for human health. Melanopsin from these cells mediates non-visual responses such as the regulation of circadian rhythms, sleep-wake cycles, changes in physiological state, alertness, cognition, and mood. The study emphasizes that the key factor for the proper functioning of ipRGCs and the stabilization of circadian rhythms is the timing of light exposure in accordance with natural light in the environment. This means that the healthy functioning of the body requires dark nights and bright days. The results of the study suggest that artificial lighting designs focusing on ipRGC pathways could significantly enhance daytime alertness, evening relaxation, and quality sleep.

White light and light enriched with a blue spectral component can increase brain activity associated with attention, cognition and alertness.

This is due to ipRGC cells, which have unique temporal response properties suited to perceiving transient changes in light and thus regulating the circadian function. Studies on brain function have found that bright white light activates areas of the brain involved in visual processing, attention and performance. This demonstrates that the intensity, spectral composition and timing of light exposure has a significant impact on cognitive abilities and overall functioning of the body.

The results of the study support the importance of the concept of biodynamic lighting, which adapts lighting conditions to the physiological needs of humans during the day, evening and night.

According to the authors, healthy lighting should take four key factors into account: the timing and length of light exposure, the intensity and spectral composition of the light and its location in the space. The most important role is played by the natural alternation of day and night, which harmonises circadian rhythms through the suprachiasmatic nucleus (SCN). Lighting applied in this way for different times of the day positively influences the visual and non-visual (NIF) effects of artificial light.

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