Study

An international study has confirmed the effectiveness of the photobiomodulatory effect of light for the treatment of age-related macular degeneration (AMD), a disease that predominantly causes vision loss in the elderly.

About study

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Title:

LIGHTSITE II Randomized Multicenter Trial: Evaluation of Multiwavelength Photobiomodulation in Non-exudative Age-Related Macular Degeneration

Author: B.Burton, M. B. Parodi, I. Jurgens, X. Zanlonghi, D. Hornan, J. Roider, K. Lorenz, M. R. Munk, C. L. Croissant, S. E. Tedford, M. Walker, R. Ruckert, C. E. Tedford James Paget University, Great Yarmouth, UK Department of Ophthalmology, Vita-Salute San Raffaele University, Milan, Italy Institut Catala de Retina, Barcelona, Spain Institut Ophtalmologique de L'Ouest-Clinique Jules VERNE, Nantes, France Peterborough City Hospital, Peterborough, UK Klinik FÌr Ophthalmologie, UniversitÀtsklinikum Schleswig-Holstein, Kiel, Germany UniversitÀtsmedizin Mainz-Augenklinik, Mainz, Germany Department of Ophthalmology, Inselspital University Hospital Bern, Bern, Switzerland LumiThera, Inc, Poulsbo, WA, USA
Date: 2. January 2023
Source: https://doi.org/10.1007/s40123-022-00640-6
PDF: LIGHTSITE II Randomized Multicenter Trial.PDF

Brief summary

A clinical study confirmed the effectiveness of photobiomodulation (PBM), a method using high wavelengths of light (red or near-infrared light) to stimulate cellular activity for the treatment and slowed progression of age-related macular degeneration (AMD). Individuals who underwent PBM treatment showed improved vision compared to the control group, which received a sham treatment.

The Valeda Light Delivery System, which uses multi-wavelength photobiomodulation (PBM), resulted in statistically significant improvements in visual acuity in patients with intermediate macular degeneration (AMD) compared to the simulator-treated group

Approximately 35% of PBM-treated eyes showed a clinically significant improvement in visual acuity by 5 or more letters after 9 months, indicating an overall improvement in visual function.
The study also found that PBM treatment prevented the formation of macular drusen (deposits) and the progression of advanced AMD.

PBM treatment was safe and well tolerated by study participants, even with the disruption in the form of the COVID-19 pandemic

The study showed that no safety problems or signs of eye damage were observed during the 10 months of the study.
In addition, according to research statistics, the patients reported a high degree of compliance with their scheduled clinic visits. This demonstrates that repeated photobiomodulation (PBM) treatment is effective for this group of patients.

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