Study

Research conducted by China’s Zhejiang University has confirmed that prolonged exposure to harmful blue light significantly damages the retina of the eye, including disrupting mitochondrial function and increasing the risk of macular degeneration.

About study

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Title:

Long-term blue light exposure impairs mitochondrial dynamics in the retina in light-induced retinal degeneration in vivo and in vitro
Author: Liyin Wang, Xin Yu, Dongyan Zhang, Yingying Wen, Liyue Zhang, Yutong Xia, Jinbo Chen, Chen Xie, Hong Zhu, Jianping Tong, Ye Shen Department of Ophthalmology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China Clinical Research Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China Department of Ophthalmology, Shaoxing Central Hospital, Shaoxing, China
Date: 24. January 2023
Source: https://doi.org/10.1016/j.jphotobiol.2023.112654
PDF: Long-term blue light exposure impairs mitochondrial dynamics in the retina.PDF

Brief summary

Chinese scientists discovered that prolonged exposure to blue light significantly thinned all layers of the retina in laboratory mice, impaired mitochondrial function and dynamics, and induced cell apoptosis during light-induced retinal degeneration. Increased mitochondrial fission and decreased fusion, along with the associated apoptosis caused by mitochondrial dysfunction, contribute to the overall retinal damage observed in the mouse model. This study highlights the potential risks of prolonged exposure to blue light, particularly regarding its impact on retinal health and mitochondrial integrity.

Long-term exposure to blue light significantly damaged the retinal layers in mice and induced cell apoptosis

C57BL/6 mice were exposed to blue light (450 nm, 800 lx) for 2 weeks (12 h light/dark period). The phototoxicity of blue light was studied in a retinal pigment epithelial cell line (ARPE-19 cells).

Blue light exposure disrupted the structure and function of mitochondria in retinal pigment epithelial (RPE) cells

Mitochondrial dynamics and associated proteins were analysed using immunohistochemistry and Western blot. Exposure to blue light disrupted mitochondrial dynamics, as reflected by an increase in fission-related proteins (DRP1, OMA1) and a decrease in fusion-related proteins (OPA1). These findings suggest that disruption of mitochondrial dynamics is a key mechanism of blue light-induced macular degeneration of the retina, particularly in RPE cells, which are particularly sensitive to oxidative stress.

 

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